An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation
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منابع مشابه
Affinity Modulation of Platelet Integrin αIIbβ3 by β3-Endonexin, a Selective Binding Partner of the β3 Integrin Cytoplasmic Tail
Platelet agonists increase the affinity state of integrin alphaIIbbeta3, a prerequisite for fibrinogen binding and platelet aggregation. This process may be triggered by a regulatory molecule(s) that binds to the integrin cytoplasmic tails, causing a structural change in the receptor. beta3-Endonexin is a novel 111-amino acid protein that binds selectively to the beta3 tail. Since beta3-endonex...
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ژورنال
عنوان ژورنال: Nature Materials
سال: 2019
ISSN: 1476-1122,1476-4660
DOI: 10.1038/s41563-019-0323-6